Abstract
The pathogenetic role of renal hypercalciuria and absorptive hypercalciuria in children with urolithiasis has not been fully evaluated. Therefore, we examined urine calcium(UCa), creatinine (UCr) and uric acid(UUa) excretion after an overnight fast and following oral calcium(1.0gm/1.73m2 body surface area) in 47 normal children and in 16 children with calcareous renal stones which were not secondary to infection, immobilization or obstruction. Milk products and supplemental vitamins were restricted for 5 days prior to the study. Urine was collected for 2 hours before and 4 hours after the calcium load and a standardized breakfast. Fasting UCa/UCr was unrelated to sex, race or age in normal children. Results are: Renal Absorptive
Serum CO2 and PTH levels were normal in all patients with hypercalciuria. OCL studies were normal in 3 children with calculi. This OCL study appears to be extremely useful in categorizing children with calcium oxalate urolithiasis and allows specific therapeutic intervention to prevent hypercalciuria in most patients. (mean;*±SD; Δrange)
Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Stapleton, F., Noe, H., Jerkins, G. et al. 1543 ORAL CALCIUM LOADING(OCL) STUDIES IN NORMAL CHILDREN AND IN CHILDREN WITH UROLITHIASIS. Pediatr Res 15 (Suppl 4), 700 (1981). https://doi.org/10.1203/00006450-198104001-01566
Issue date:
DOI: https://doi.org/10.1203/00006450-198104001-01566
