Abstract
A protocol was started in 1976 for the treatment of ALL. It included 3 injections of IT MTX-DMT during the induction, another 3 early in remission followed by one injection every 3 months as prevention of CNS disease.Thus far 24 (8,9%) CNS relapses were observed in 270 patients who achieved complete remission(median: 18 months, range: 1 to 33). Data from earlier protocols of our group, which included radiotherapy (RT) to cranium plus 5 doses of IT MTX showed 49 patients (11,6%) of a total of 443 who experienced CNS relapse. The comparison of the incidence of CNS leukemia of both preventive methods according to life table analysis is the following:
We conclude that in comparison with earlier protocols which included RT the present regimen compares favourably in standard and high risk patients.
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Braier, J., Pavlosky, S., Sackmann Muriel, F. et al. 6 EFFECTIVENESS OF PREVENTION OF CNS LEUKEMIA WITH INTRATHECAL (IT) METHOTREXATE (MTX) AND DEXAMETHASONE (DMT) IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL). Pediatr Res 15, 184 (1981). https://doi.org/10.1203/00006450-198102000-00063
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DOI: https://doi.org/10.1203/00006450-198102000-00063
