1622 BROVIAC CATHETERS FOR PROLONGED ANTIBIOTIC ADMINISTRATION IN CYSTIC FIBROSIS PATIENTS

Abstract

An efficient and safe program for continuous home administration of parenteral antibiotics was developed for chronically ill cystic fibrosis children. Six patients, ages 9 to 20 yrs, who required frequent hospitalizations for pseudomonas bronchitis had Broviac or Hickman catheters placed under general anesthesia. Catheters were utilized over intervals of one month to two years. A combination of tobramycin (5-7.5 mg/kg/day) and carbenicillin or ticarcillin (300 mg/kg/day) was given every six to eight hours by patients or their parents. Peak tobramycin levels between 5 - 10 μg/ml were achieved. Compared to a control period prior to beginning the program, a decreased frequency of hospitalizations for pulmonary symptoms was noted in 4 of 6 patients. All patients benefited by their ability to maintain normal activities at home and at school. No objective improvement in pulmonary function tests utilizing peak flow measurements was observed in this patient group. No catheter-related complications were observed. Two catheters required repair because of leakage of the external segment. Prolonged administration of antibiotics utilizing the Broviac catheter may benefit some patients with cystic fibrosis. However, the long term effects of this therapy on the progression of their pulmonary disease are unknown.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD