Abstract
Yellow hyaline membrane (YHM) have been correlated with hyperbilirubinemia (HBILI) and with bronchopulmonary dysplasia. Also data have suggested a protective effect of HBILI on O2 damage to lungs and a role of phototherapy (P) in the development of lung damage. To test the relationship of P, HBILI and high FIO2, and to develop a model for study 7 to 13 day old GUNN rats (jj and Jj phenotypes) were exposed to four experimental conditions for 24 to 72 hours: I) FIO2 > .75+P, II) FIO2 > .75 without P, III) FIO2 .21+ P and IV) FIO2 .21 without P. Hct. Indirect Bili were measured. The lungs were examined in a masked fashion.
Lung Path = Pulmonary hemmorrhage ± hyaline membranes.
The Data indicate no effect of O2 and P in acute phase lung damage but suggest a protective effect of HBILI. Additional study with longer exposure and larger numbers are needed.
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Bowen, F., Porat, R., Hausman, D. et al. 1631 PULMONARY CHANGES IN NEONATAL GUNN RATS EXPOSED TO O2 AND PHOTOTHERAPY. Pediatr Res 15 (Suppl 4), 715 (1981). https://doi.org/10.1203/00006450-198104001-01648
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DOI: https://doi.org/10.1203/00006450-198104001-01648