Abstract
Twenty two tests were performed in 16 children in remission: 3 of I.V.tolbutamide (I.V.T.T.),11 of I.V.glucose(I.V.G.T.) and 8 of post-tolbutamide glucose (P.T.G.T.) and in 10 normal children: 3 I.V.T.T.,3 I.V.G.T. and 4 P.T.G.T.. Glucose, insulin, glucagon and growth hormone were measured. The glycemic fall(K,Amatuzio) was normal in average (2.24) with a range of 1.47 and 3.3. The insulinemia in the remission group was 9.6±5.4 uU/ml, not different from the normal group: 11.4±7.3 uU/ml, but, there were no secretion peaks with any of the used stimuli. The basal glucagonemia in the remission group was similar to normal (143±42 pg/ml and 129±51 pg/ml) and no modifications were noted after tolbutamide or glucose administration. The growth hormone responses to glucose were normal in the remission group.
The studies performed show that the disappearance fo the clinical symptoms during remission is not due to an increase in the insulin response to stimuli.
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Knopf, C., Cresto, J., Dujovne, I. et al. 27 STUDY OF THE HORMONAL BEHAVIOUR (INSULIN, GLUCAGON AND GROWTH HORMONE) IN 16 CHILDREN DURING THE REMISION OF THEIR DIABETES. Pediatr Res 15, 187 (1981). https://doi.org/10.1203/00006450-198102000-00084
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DOI: https://doi.org/10.1203/00006450-198102000-00084
