Abstract
It was previously demonstrated that 3H Thymidine uptake into human lectin-activated lymphocytes is related to plasma GH-dependant growth factors, thymidine activity (TA) thus measuring plasma somatomedin activity as defined by Daughaday et al.
TA has been measured in 20 children with average stature (A) and 37 constitutionnally tall children with 2 to 4 SD advanced height (T), age 4 to 16 years. In both groups, mean ± SEM TA is higher after age 10, and the difference is significant when TA is related to bone age (BA) ; in A, 0.78 ± 0.06 U/ml before BA 10, 1.02 ± 0.05 beyond BA 10 (p <0.005) ; in T, 0.75 ± 0.05 U/ml before BA 10, 1.05 ± 0.05 beyond BA 10 (p < 0.01). Yet, there was no significant difference between T and A children. In both groups TA was correlated with BA (r = 0.572, p < 0.001).
In individual subjects, no correlation was found between TA and sulfation activity. The discrepancies between these two biologic measurements of plasma growth activity could be of physiologic significance.
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Schimpff, R., Bozzola, M., Thieriot-Prevost, G. et al. Plasma growth factors measured as thymidine activity in children with average and tall stature. Pediatr Res 15, 1554 (1981). https://doi.org/10.1203/00006450-198112000-00112
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DOI: https://doi.org/10.1203/00006450-198112000-00112
