Abstract
LH deficiency and normal or high FSH were reported in prepubertal cryptorchid children.In order to test the influence of testicular retention on gonadotrophin secretion,13 surgical treated and 5 HCG treated unilateral cryptorchid children(aged 4-5 years)were compared with a control group of 10 normal children(aged 4-5 years). The response to LH-RH(100 μg/m2/i.v.)was evaluated in all subjects,in cryptorchids also 2 years after treatment.No difference was observed between treatments and then the data were pooled for statistical analysis.LH response to LH-RH was significantly(p<0.01)lower in cryptorchid children both before(1.18±0.44ng/ml)and after treatment (1.27±0.39ng/ml)than in controls(2.28±0.35ng/ml).Cryptorchid children shew significant(p<0.01,paired t test)higher FSH peak levels before treatment(1.81±0.18ng/ml)than 2 years after(1.48±0.59ng/ml). Nevertheless no significant difference of basal or stimulated FSH was observed between cryptorchid and controls.The explanation for these results might be the rise of the inhibin production by the testis artificially descended. Inhibin,a not yet defined sustance, exerts a negative feedback on FSH secretion.
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Tato, L., Belligoli, A., Avanzini, S. et al. Influence of testicular retention on Pituitary response to LH-RH in prepubertal unilateral cryptorchid children. Pediatr Res 15, 1566 (1981). https://doi.org/10.1203/00006450-198112000-00184
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DOI: https://doi.org/10.1203/00006450-198112000-00184
