Abstract
Elevated basal gonadotropins in primary hypothyroidism (pHT) and restoration to normal values by L-thyroxine replacement have been reported by us and others in prepubertal girls. We now report GnRH responses in 4 of these girls after 1 y L-thyroxine 0.1 mg/d given orally (Rx). All are euthyroid, pubertal stage P2 and x Bone Age (BA)=10.3±0.7 y. Mean basal and area under curve LH and FSH responses (x±SE) to GnRH 2.5 ug/kg IV bolus were compared with responses of 7 normal prepubertal P1 girls x BA=6.5±1:
FSH responses to GnRH were pubertal but the expected increase in basal and GnRH induced LH secretion did not occur. Thyroxine Rx 1) restored estradiol secretion to pubertal values in absence of pubertal LH secretion, and 2) increased the LH disappearance rate post GnRH infusion. Possibly thyroxine alters the metabolic clearance rate of either or both gonadotropins or estradiol. Clear elucidation of these interesting observations of abnormal mechanisms of pubertal development warrant further study.
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Huseman, C., Kugler, J., Singh, S. et al. 18 HASHIMOTO'S THYROIDITIS IN PUBERTAL GIRLS: SUBNORMAL GONADOTROPIN SECRETION. Pediatr Res 15 (Suppl 4), 442 (1981). https://doi.org/10.1203/00006450-198104001-00027
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DOI: https://doi.org/10.1203/00006450-198104001-00027
