Abstract
The purpose of this study was to assess the extent of intraoperative myocardial compromise during cardiopulmonary bypass. A radionuclide ejection fraction (EF), cardiac output (CO), and left ventricular volume (V) determination, and inulin clearance were performed on 20 children (1-19 years old) 2-3 hours after total surgical repair of their congenital heart defects. Three measurements of EF, CO, and V were made at hourly intervals in 7/20 patients post-op. In spite of changes in CO and V, EF and heart rate did not change significantly. The duration of aortic cross clamp time (CT) reflects the potential for intraoperative myocardial insult. Immediately after surgery EF correlated with CT (r=−.77, p <.001) but not with pre-op EF. Late post-op (1 month-1 year) EF correlated with pre-op EF (r=.71, p <.05). Glomerular filtration rate correlated with EF (r=.76, p <.01). EF in the immediate post-op period reflected intraoperative myocardial compromise. Late post-op EF showed recovery from immediate post-op lows and was most influenced by pre-op EF. Low immediate post-op EF was associated with reduced renal function independent of the effect of altered cardiac output.
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Covitz, W., Eubiq, C., Sellers, B. et al. 124 IMMEDIATE EFFECTS OF CARDIAC SURGERY ON MYOCARDIAL AND RENAL FUNCTION IN CHILDREN. Pediatr Res 15 (Suppl 4), 460 (1981). https://doi.org/10.1203/00006450-198104001-00133
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DOI: https://doi.org/10.1203/00006450-198104001-00133
