Abstract
The cardiac response to Tolazoline was carefully monitored by echocardiography (ECHO) in 6 patients who had persistent foetal circulation (PFC) and were treated with Tolazoline (T). Echo was performed just prior to T and 10 mins., 1, 4 and 24 hours after initial therapy. The mean weight was 2163 g.(range 1080-3870 g), gestational ages 28-41 wks. Two full term neonates had severe meconium aspiration and 4 premature neonates had hyaline membrane disease and asphyxia. All had labile PO2's and were extremely difficult to manage with maximal ventilation. T was given for hypoxia or to attempt to reduce ventilation requirements. Five patients responded immediately with an increase in PO2 of > 20 torr. The other had incompletely resolved pneumothoraces.
Pre and post therapy ECHO results for ejection fraction (EF), fractional shortening (FS), velocity of circumferential fibre shortening (VCF) left ventricular (LV) and right ventricular (RV) pre-ejection period (PEP) to ejection time (ET) ratios (PEP/ET):
These results show marked abnormalities in left and right sided cardiac function prior to T and a very rapid improvement in right sided indices followed by the left sided indices with T.
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Sandor, G., McNab, A., Ebelt, V. et al. 189 NON-INVASIVE EVALUATION OF THE EFFECT OF TOLAZOLINE IN PERSISTENT FOETAL CIRCULATION. Pediatr Res 15 (Suppl 4), 471 (1981). https://doi.org/10.1203/00006450-198104001-00198
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DOI: https://doi.org/10.1203/00006450-198104001-00198
