Abstract
Regional brain blood flow (RBBF) was studied during and after asphyxia (Asph) using radio-nuclide microspheres in 20, 1-6 day old lambs. Preterm lambs (133 days of gestation) were delivered alive after a fetal injection of glucocorticoid. A dead space added to the airway produced acidosis, hypoxia, and hypercarbia. Control lambs (no dead space but studied similarly) showed no changes in RBBF. Baseline values and % increase in RBBF during (Asph) were (M±SEM):
The data showed that in both term and preterm subjects regional distribution of blood flow to neonatal brain is characterized by a similar pattern as in the fetus with a higher flow to the subcortical areas. Asphyxial insults resulted in increments in blood flow to all regions of the brain but more so in the sub-cortical areas suggesting a preferential protection of the vital areas of the brain. Supported by the March of Dimes.
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Stonestreet, B., Laptook, A., Schanler, R. et al. 295 EFFECTS OF ASPHYXIA ON REGIONAL BLOOD FLOW IN THE NEONATAL BRAIN. Pediatr Res 15 (Suppl 4), 489 (1981). https://doi.org/10.1203/00006450-198104001-00306
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DOI: https://doi.org/10.1203/00006450-198104001-00306
