Abstract
The relationships of serum (Se) to Saliva (Sa) concentrations of Theophylline (Theo) and total methylxanthines (Mx) (Mx = Theo + Caffeine (Caf)) have been established in neonates treated with Theo for apnea (J.Pediatr.96:494,1980). Serum to Sa relationships derived with additional studies have been crossvalidated against the old data. The standard deviations (SD) and correlation coefficients (R) for the Se to Sa relationships are presented below. Data for Mx is presented because of Theo to Caf conversion in neonates.
Crossvalidation results indicate that R is high for Mx using both models and for Theo only for the ratio model. The discrepancy between Theo and Mx results may be caused by the wide interindividual differences in conversion from Theo to Caf.
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Khanna, N., Somani, S., Boyer, A. et al. 341 CROSSVALIDATION OF SERUM TO SALIVA RELATIONSHIPS OF THEOPHYLLINE AND TOTAL METHYLXANTHINES IN NEONATES. Pediatr Res 15 (Suppl 4), 497 (1981). https://doi.org/10.1203/00006450-198104001-00352
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DOI: https://doi.org/10.1203/00006450-198104001-00352
