Abstract
Insulin antibodies were determined in sera from 38 JD children. 8 children were started on purified porcine insulins (PPI). 16 got insulin NPH alone, and 14 non-purified, of whom 9 were later transferred to PPI. Serum insulin antibodies were measured by qualitative and quantitative methods using beef (B) and pork (P) antigens. 12/38 JD children had insulin antibody levels as low as normal children, irrespective of the type of insulin used. The conc. of antibodies using radiolabelled (B) or (P) insulins as antigens were strongly correlated, by both the qualitative (p<0.01) and quantitative (p<0.01) methods. JD children with better score for diabetic control had significantly lower levels of insulin antibodies against B (p<0.05) and P (p<0.05) than those with poor diabetic control. There was also a significant correlation between mean HbA1 conc. and (B) and (F) mean insulin antibody cone. (p<0.01). Finally, patients treated with PPI had significently lower levels of antibodies than patients treated with NPI (p<0.05).
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Bistritzee, T., Theodor, H. & Sack, J. Insulin antibodies, HbA1 in juvenile diabetic (JD) children treated with purified and non-purified insulins (NPI). Pediatr Res 15, 82 (1981). https://doi.org/10.1203/00006450-198101000-00069
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DOI: https://doi.org/10.1203/00006450-198101000-00069
