Abstract
Dehydroepiandrosterone (DHEA), 17 OH-progesterone (17OHP), androstenedione (Δ4A), testosterone (T), cortisol (F), PRL and IGF I were measured in plasma of pubertal girls (age 13,2±0,2 yrs) with tall stature before and on HDE. Results (mean ± SEM(n):
All AS except F decreased. IGF I remained unchanged and PRL increased. The reducing effect of HDE on AS could be due to reduced production, increased metabolism and/or altered protein binding, but probably not to adrenal enzyme changes. F could remain normal or increase, because of increased transcortin. It is concluded that the reduction of adult height in HDE-treated girls is due neither to suppression of IGF I nor to stimulation of any of the measured adrenal androgens. Supported by the Swiss National Science Foundation (Grants No. 3.883.077 and 3.901.077).
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Bucher, H., Zachmann, M., Illig, R. et al. Response of adrenal steroids (AS), prolacttn (PRL) and insulinlike-growth-factor I (IGF I) to high dose estrogens (HDE) in pubertal girls. Pediatr Res 15, 83 (1981). https://doi.org/10.1203/00006450-198101000-00072
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DOI: https://doi.org/10.1203/00006450-198101000-00072
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