Abstract
The records of 61 pts. with Reyes Syndrome (RS) seen at the Upstate Medical Center during the past 8 years were reviewed. Measurements of serum salicylate and acetaminophen (APAP) concentrations were made at the time of admission in 37 and 21 pts. respectively. Measurable levels of salicylate were found in 28 pts. (76%) with a mean value of 5.5 mg/dl (range 0.2 mg/dl to 36 mg/dl). Salicylate levels are summarized in the following table according to presenting stage.
The mean levels in this table are not significantly different. Salicylate and APAP levels did not correlate with the degree of liver enzyme elevations, blood ammonia levels or phenobarbital half-life. Nine of 22 pts. who expired or had serious sequelae had admission salicylate levels measured. The mean level was 8.8 mg/dl. In 19 of 39 survivors without sequelae in whom the salicylate level was measured the mean level was 4.0 mg/dl (p<.1). In the 21 pts. in whom admission APAP values were determined, measurable levels were noted in 7 pts. (mean 11.4 μg/ml, range 2.2-40 μg/ml). The high prevalence of measurable salicylate levels suggests a possible relationship between salicylate ingestion and RS. These data also indicate a correlation between salicylate level and outcome.
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Rodgers, G., Weiner, L., Mcmillan, J. et al. 490 ASPIRIN AND ACETAMINOPHEN LEVELS IN CHILDREN WITH REYES SYNDROME. Pediatr Res 15 (Suppl 4), 522 (1981). https://doi.org/10.1203/00006450-198104001-00503
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DOI: https://doi.org/10.1203/00006450-198104001-00503
