Abstract
61 infants from two weight categories were divided into 2 groups. The IT group received its daily PN during 18 hours plus six hours of noninfusion time and the CS group received its PN continuously during 24 hours. CBC, electrolytes, BUN, creatinine, glucose, liver function tests, & bili T/D were done twice weekly. There was no significant difference in these studies between the IT and CS groups except as noted below. Micro blood sugars were done on the IT group as explained below. Similar tests done on the CS group, obviously, did not show any hypoglycemia.
The duration of PN was longer for infants who developed CJ (x 42.7ds) compared with those who did not develop CJ (x 20.1ds). CJ occurred on x day 16 of PN for the IT group and on x day 23 for the CS group.(N.S.) In the IT group ≤1500 gms, hypoglycemia frequently occurred during the noninfusion times.
We conclude that the incidence of CJ does not change between IT PN and CS PN and that hypoglycemia is a significant risk for the IT PN infants ≤1500 gms.
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Deming, D., Vain, N., Georgeson, K. et al. 539 INCIDENCE OF CHOLESTATIC JAUNDICE (CJ) IN CONTINUOUS (CS) AND INTERMITTENT (IT) HYPERALIMENTATION (PN): A PROSPECTIVE STUDY. Pediatr Res 15 (Suppl 4), 530 (1981). https://doi.org/10.1203/00006450-198104001-00553
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DOI: https://doi.org/10.1203/00006450-198104001-00553
