Abstract
A longitudinal study was carried out to see the effects of CA (20mg/kg b.w.) given s.c. daily to male Wistar rats during their multiphase sexual development between age day 20 and day 90.Blood was collected from the same animals at regular intervals, and plasma concentrations of LH,FSH,T,DHA,GH,insulin,Somatomedin (SM) and T4 together with body weight were examined. In the CA-treated animals body weight and its velocity were suppressed. When CA was withdrawn at different phases of maturation, catch-up growth was observed at all time-points except age day 80. The CA-treated animals showed multiple effects on their hormonal levels; FSH being increased at all time-points, LH increment after day 30 then increasing and DHA increasing after day 30. Following the withdrawal of CA, all peripheral hormones, except GH, recorded non - malization. The reversibility of growth suppression induced by CA is age-dependent and therefore has wider clinical implication. In contrast to the findings in humans, the antigonadotropic effect of CA seen in prepubertal animals was later overcome by antiandrogenic effect.
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Ranke, M., Hildebrand, P., Rudolph, C. et al. Age-dependent effects of cyproterone acetate (CA) on growth and peripheral hormones in the male rat. Pediatr Res 15, 87 (1981). https://doi.org/10.1203/00006450-198101000-00095
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DOI: https://doi.org/10.1203/00006450-198101000-00095
