Abstract
BHM composition and nutritional adequacy for infants < 1500g has not been established. We have randomized 65 infants < 1500g to ad lib feeds of F (Similae Special Care, a protein and mineral enriched formula designed to sustain intrauterine-like growth) or frozen BHM until infants weighed 2000g. BHM was low in fat (2.3%) and calories (bomb analysis 58 cal/100g), a finding also recently noted by Carroll. BHM infants ingested more milk (192 vs 162 ml/kg/d) but fewer calories (121 vs 142 cal/kg/d); grew less in weight (14 vs 30 g/d), length (0.7 vs 1.1 cm/wk), and FOC (0.8 vs 1.2 cm/wk); and at 37 wks post-conception were less responsive to visual & auditory stimuli (Brazelton orientation items, mean score = 2.4 vs 3.6; p < 0.05). Amino acids, BUN, and pH values were similar. Findings at blind evaluation 92 wks post-conception:
Bayley developmental scores were higher for F than BHM infants at 92 wks (PDI:92 vs 78; p<0.05; MDI:89 vs 76, p=0.13). Birthweight, gest. age, and need for ventilation were similar for BHM and F infants seen at 92 wks. F supports near intrauterine growth rates and may confer short and long term advantages over BHM for infants < 1500g.
*Actual age minus age at which measurements equal 50th percentile.
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Tyson, J., Lasky, R., Mize, C. et al. 651 GROWTH & DEVELOPMENT OF INFANTS < 1500 g FED BANKED HUMAN MILK (BHM) OR PREMATURE FORMULA (F). Pediatr Res 15 (Suppl 4), 549 (1981). https://doi.org/10.1203/00006450-198104001-00664
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DOI: https://doi.org/10.1203/00006450-198104001-00664
