Abstract
Hyperglycemia (H), plasma glucose >150mg%, is often noted among newborns (NB) undergoing surgery with general anesthesia. To find the cause of H, baseline, preinduction, postinduction and postsurgical plasma samples were drawn for glucose (G), insulin (I), and cortisol (C). Glucose infusion was maintained constant with infusion pumps for 4-6 hrs prior to and during surgery. Additional fluid loss during surgery was replaced by I.V. fluids without dextrose. Sixteen NB undergoing elective surgery were included in the study. Mean weight ±S.D. at time of surgery was 3040±1546g; postnatal age ranged from 1 day to 40 weeks and duration of general anesthesia, 83±35 minutes. Glucose was infused at a rate of 4.0±1.2mg/kg/min.
H was found in 10/16 N.B.; infants with H had sig. (p<.01) lower weight (2241±712g vs 4367±1248g) than infants without H but there were no sig. differences in postnatal age or duration of surgery between these two groups. In conclusion: (1) G rises significantly soon after induction and remains elevated during surgery. (2) I changes are minimal and variable. (3) C does not change significantly until end of surgery. Factors other than C and I appear to cause H during surgery.
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Srinivasan, G., Jain, R., Kiam, D. et al. NEONATAL CARBOHYDRATE HOMEOSTASIS DURING SURGERY. Pediatr Res 18 (Suppl 4), 300 (1984). https://doi.org/10.1203/00006450-198404001-01242
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DOI: https://doi.org/10.1203/00006450-198404001-01242
