Abstract
Although the association between hypertonic medications and the development of Necrotizing Enterocolitis is unclear, hyperosmolar materials (more than 400 mOsm/kg H2O) can cause an osmotic diuresis, loose stools and probable mucosal injury.
Osmolalities on the seven most common medications used in our nursery were measured by freezing point depression and checked with calculations based upon standard equations.
It May be necessary to calculate the osmolalities of medications offered to growing premature infants and consider using parenteral preparations.
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Martin, G., Jacks, R., Snider, W. et al. OSMOLALITIES OF ORAL AND PARENTERAL MEDICATIONS USED IN THE NEONATAL INTENSIVE CARE UNIT. Pediatr Res 18 (Suppl 4), 334 (1984). https://doi.org/10.1203/00006450-198404001-01445
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DOI: https://doi.org/10.1203/00006450-198404001-01445
