Abstract
The macrosomia of infants of diabetic mothers (IDM) is believed due to fetal hyperglycemia & hyperinsulinemia. Serum INO, a possible growth factor, is elevated among IDM. Therefore, we studied whether elevated INO is associated with IDM growth stigmata. Pregnant (27-day) rabbits were infused with insulin IV for 48 hrs to maintain blood glucose between 45-90 mg/dl. Group 1 (4 does): continuous INO infusion, 2 gm/kg/day; Group 2 (3 does): no INO. All had free access to water & lab chow. The groups had similar IV total fluid intake/kg maternal serum glucose & insulin/kg/hr. The does were sacrificed on pregnant day 29 and the fetuses studied for growth.
Serum INO was significantly higher in Group 1 fetuses than in Group 2 (<.001), with no significant fetal serum C-peptide differences between groups. Group 1 (INO) fetuses had significantly higher body, liver & brain wt., but lung weights were not different (Table).
We have demonstrated that excess INO, found also in IDM, increases body, liver & brain wt. despite low maternal & fetal glucose. This suggests possible importance of hypermyoinositolemia in the pathogenesis of macrosomia in the IDM.
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Wozniak, P., Sills, J., Hallman, M. et al. MYOINOSITOL (INO) EXCESS INDUCES FETAL GROWTH IN HYPOGLYCEMIC RABBITS. Pediatr Res 18 (Suppl 4), 356 (1984). https://doi.org/10.1203/00006450-198404001-01577
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DOI: https://doi.org/10.1203/00006450-198404001-01577
