EVALUATION OF SINGLE DOSE GENTAMICIN THERAPY (ST) IN COMPLICATED URINARY TRACT INFECTIONS (UTI)

Abstract

ST is effective in uncomplicated lower UTI but its efficacy in complicated cases has not been studied. Eighteen (18) consecutive cases (all girls) of UTI associated with confirmed Pyelonephritis and/or structurally abnormal urinary tract (AUT) were treated with ST. An equal number of similar cases (all girls) were treated alternately with a 10 day conventional therapy (CT) as control. Each patient was examined at least 4 times during 1 month follow-up for recurrence and cure (defined as absence of recurrence). The two groups were comparable in age, sex and incidence of AUTs. Cure and recurrence rates 2-4 days and 1 month after therapy are presented (table).

Urine was sterilized at 2-4 days in almost every case in both groups. Recurrence and cure rates were comparable (P > 0.5). All recurrences were reinfections except one in ST group which was a relapse. ST was as effective as CT. Further studies would help confirm the role of ST in complicated UTIs.

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