Abstract
Overall renal function is thought to increase during development, but it is unclear if a continuum of changes occurs during as well as after nephrogenesis (2½-3 weeks in rabbit). In previous studies (AJP,1983) we found no change in BLM characteristics in outer cortical proximal convoluted tubules (PCT) during nephrogenesis. This finding is not surprising since tubules from the outer nephrogenic zone are of similar maturity even with advancing age. We therefore studied juxtamedullary (JM) tubules to look for developmental changes in the BLM from more mature tubules. 65 early collapsed JMPCT were tightly crimped with micropipets. Changes in cell volume, assessed by measuring outer diameter with an image splitting eyepiece, were used to measure rate of trans BLM fluid movement as tubule volume increased in 10−4 M ouabain. Results are M±SE.
Tubule size and swelling rate were constant in the first 17 days of life but increased by 4-6 weeks. Early changes in BLM surface area were also inapparent. We suggest from this data and that of Arant (J.Peds,1978) and Schwartz (AJP,1983) that nephron function during nephrogenesis is relatively dormant and increases only after nephrogenesis is completed.
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Linshaw, M., Bauman, C. & Welling, L. MATURATIONAL CHARACTERISTICS OF RABBIT BASOLATERAL MEMBRANE (BLM). Pediatr Res 18 (Suppl 4), 364 (1984). https://doi.org/10.1203/00006450-198404001-01628
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DOI: https://doi.org/10.1203/00006450-198404001-01628
