Abstract
CAPD is a growing modality of treatment for children with ESRD; however peritonitis is the major complication. We therefore evaluated serum IgG levels and immunoglobulin (Ig) production in 14 children undergoing CAPD for 18.2m (r=4-46m). Mean age was 13.9 yrs (r=0.8-20.5). Peripheral blood lymphocytes (PBLs) were isolated and cultured spontaneously with pokeweed mitogen (PWM), protein A from Staphylococcus aureus or Candida albicans for 12 days. Culture supernatants were assayed for IgG and IgM by enzyme-linked immunosorbent assay (ELISA). Final serum IgG levels correlated with initial serum IgG (r=0.81, p<0.01). Mean initial serum IgG levels correlated inversely with the number of episodes of peritonitis (r=0.61, p<0.02). Ig production by pts PBLs was significantly reduced in spontaneous or activated cultures compared to normal controls. The increment in IgG production by PWM-stimulated lymphocytes from spontaneous cultures tended to correlate inversely with the frequency of peritonitis. A depressed humoral response in children with ESRD undergoing CAPD may predispose to peritonitis.
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Lemire, J., Salusky, I., Sakai, R. et al. IMMUNOLOGICAL PARAMETERS AND INCIDENCE OF PERITONITIS IN CHILDREN ON CAPD. Pediatr Res 18 (Suppl 4), 365 (1984). https://doi.org/10.1203/00006450-198404001-01630
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DOI: https://doi.org/10.1203/00006450-198404001-01630
