Abstract
The effects of acute (A) (0.25 ug/min/kg body wt. over 2 hrs) and chronic (C) (0.50 ug/kg over 4 days) aldosterone infusion (Aldo-I) on active urinary kallikrein (UKall) and Na+ excretion (UNa+V) were studied in young (95-115 days, n=6) and old ( 125 days, n=8) fetal lambs (term 145 days) chronically instrumented. A-Aldo-I was not associated with changes in plasma electrolytes concentration but produced a significant decrease in UNa+V in both groups of fetuses and a rise in UKall in young fetuses. C-Aldo-I produced a significant (p<0.05) rise in plasma Na+ (142±1 to 147±1 meq/1 meq/1) and decline in plasma K+ (4.7±0.3 to 4.0±0.2 meq/l) in old fetuses and was associated with decreases in UNa+V and increases in UKall in both groups of fetuses.
All values were back to baseline levels 3 days after stopping C-Aldo-I. The present results demonstrate that Aldo is a potent modulator of Na+ reabsorption and UKall production very early during gestation and suggests a link between the kallikrein-kinin and renin-angiotensin-aldosterone system during fetal life.
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Robillard, J., Nakamura, K., McWeeny, O. et al. ALDOSTERONE--A POTENT STIMULATOR OF THE RENAL KALLIKREIN-KININ SYSTEM DURING FETAL LIFE. Pediatr Res 18 (Suppl 4), 368 (1984). https://doi.org/10.1203/00006450-198404001-01651
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DOI: https://doi.org/10.1203/00006450-198404001-01651
