Abstract
Hematuria may precede urolithiasis in children with hypercalciuria (HCU). To determine the incidence and nature of HCU in children with hematuria, urinary calcium excretion was examined in 83 consecutive patients with hematuria without urolithiasis, proteinuria, infection, sickle cell disease or systemic disease. HCU (urinary calcium >4mg/kg/d) was present in 23 children.
Oral calcium loading tests in HCU patients revealed absorptive HCU in 10 and renal HCU in 13. Serum PTH and bicarbonate concentrations were normal in all children with HCU. Hematuria resolved with anticalciuric therapy in 20 of 23 patients. Two children with HCU developed urolithiasis. In 4 patients with HCU, renal histology was normal in 3 and 1 patient had IgA nephropathy. No etiology of hematuria was found in 39 of 60 children with unexplained hematuria. We conclude that HCU occurs frequently in children with hematuria and that assessment of urinary calcium excretion is indicated in the evaluation of hematuria.
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Stapleton, F., Roy, S., Noe, H. et al. HYPERCALCIURIA: AN IMPORTANT CAUSE OF HEMATURIA IN CHILDREN. Pediatr Res 18 (Suppl 4), 371 (1984). https://doi.org/10.1203/00006450-198404001-01669
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DOI: https://doi.org/10.1203/00006450-198404001-01669
