Abstract
No previous reports have described the use of FNAB in children. 70 FNAB were performed in 11 renal transplant (Tx) recipients with a mean age of 14.6 yrs. during the initial 6 post Tx months. The number of serial FNAB's ranged from 1-15. Initial local infiltrative anesthesia was replaced with surface anesthesia (ethyl chloride) because of inadequate specimens without subjective discomfort. An increase in adequate FNAB specimens from 44% to 81% resulted. No complications were noted. Serous fluid was obtained in 4 instances: perirenal lymphatic collection (2) and peritoneal fluid from CAPD (2). Ultrasonography facilitated subsequent FNAB's in these patients.
Cytologic interpretations of the FNAB yielded a corrected cellular index (C.I.) indicating an increment of Tx mono-nuclear cells over those in the peripheral blood. A correlation between an increase in the C.I. (>3.0) and a rise in the serum creatinine (Cr) level (>30% increase) was noted. The increment in the C.I. occurred as early as 10 days prior to the rise in the serum Cr level. Resolution of the rejection episode coincided with a fall in the C.I. in 100% of cases (2/2). No false CI's were noted.
We conclude that the FNAB is an effective tool for monitoring immunologic events in renal Tx recipients.
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Tabak, M., Du Puis, M., Ettenger, R. et al. THE USE OF FINE NEEDLE ASPIRATION BIOPSY (FNAB) FOR MONITORING IMMUNOLOGIC PHENOMENA POST-RENAL TRANSPLANTATION IN CHILDREN. Pediatr Res 18 (Suppl 4), 372 (1984). https://doi.org/10.1203/00006450-198404001-01672
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DOI: https://doi.org/10.1203/00006450-198404001-01672
