Abstract
Haemorheologic and lipidemic tests were performed in 3 groups of children: 20 with obesity (14m,6f., age 11.4±2.6y) defined as a weight excess of at least 20% (OC) ; 16 with type 1 diabetes in compensated phase (7m.,9f.,age 11.9±2.OY) (DC) ; and 20 normal children (15m.,5f.,age 11.9±2,1y.) (NC). For haemorheologic tests by analysis of variation the 3 groups were significantly different for blood viscosity (BV,p<0,01 for both 230 and 23/sec-1), plasma viscosity (PV,p<0,01) and fibrinogen (Fg,p<0,01), but not for haematocrit (HT) and erythrocyte filtration time (1ml.20% erythrocyte suspension in autologous plasma, EFT). The differences were entirely due to OC and not to DC:BV 230 sec. was cP 4.63± 0.46 in OC versus 4.19±0.30 in NC (p<0.005); PV was cP 1.66± 0.08 in OC vs. 1.55±0.08 in NC (p<0.001); and FG was mg% 341± 53 in OC vs. 254±82 in NC (p<0.001) for lipidemic tests, OC had significantly increased triglycerides (p<0.05), FFA (p<0.05) but not cholesterol, and significantly lowered Lipoprotein (p<0.01). DC differed from normals only for increase in FFA (p<0.01). These data show that early haemorheologic changes, esp. in hyper Fg and increased PV and DV are observed in childhood obesity rather than in juvenile diabetes. These changes do not involve EFT, in either condition. The chronic metabolic disorder due to obesity affects the lipidemic profile much more than type 1 diabetes.
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Ealsamo, A., Cocceri, S., Argento, R. et al. Haemorheologic and lipidemic parameters in obesity and diabetes. Pediatr Res 18, 1218 (1984). https://doi.org/10.1203/00006450-198411000-00107
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DOI: https://doi.org/10.1203/00006450-198411000-00107
