Abstract
Diabetic children seem to be at risk to develop thyroid autoimmune disease. 110 diabetic children (48 fem, 62 males, mean age 12,3±3,8yrs.) were HLA-DRtyped and their sera were tested for the occurence of thyroid autoantibodies (TAB:antithyroglobulinantibodies and microsomal antibodies). Thyroid function was determined by measurement of thyroxine (T4) and thyrotropin (TSH) levels. The control group (n=50) was age- and sex matched. TAB were found in 18% of the diabetic children and in 6% of control (p 0,05). There was a predominance of females in the TAB positive group (m:f = 1:1,8). 60% of the TAB-positive diabetic children were positive for HLA-DR3 compared to 54% of the TAB-negative diabetic children. Only one diabetic child had mild hypothyroidism. We conclude that HLA-DR3 does not represent an additional risk factor for the development of thyroid autoimmune disease and thyroid dysfunction is a rare phenomenon in diabetic children.
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Frisch, H., Schober, E., Weissel, M. et al. HLA-DR ANTIGENS AND THYROID AUTOANTIBODIES IN DIABETIC CHILDREN. Pediatr Res 18, 1219 (1984). https://doi.org/10.1203/00006450-198411000-00112
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DOI: https://doi.org/10.1203/00006450-198411000-00112
