Abstract
Reference values for the excretion of cyclic adenosine 3′, 5′monophosphate (cAMP) in children are few. Data are mostly based upon a 24 h urine collection We measured the urinary cAMP by a competitive protein-binding assay. Reference values for the urinary cAMP in spot urine obtained in the morning from 142 healthy children aged 2 - 200 months are reported. A significant positive correlation between urinary cAMP and creatinine excretion appeared (r 0.68, p<0.01), and for which reason the cAMP excretion was creatinine corrected (cAMP/crea.).
The mean value (and 95% significance limits) for (cAMP/crea.) were 747 μmol/mol (254-2206 μmol/mol).
A logarithmic transformation of the (cAMP/crea.) ratio showed an even distribution. Log (cAMP/crea.) values were related to age or body surface with decreasing values for increasing age or body surface area (r-0.55 and -0.57 respectively, p<0.001).
It is concluded that spot urine for measurement of urinary cAMP excretion appears simple and preferable as compared to a 24 h urine collection in children.
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Thode, J., Jacobsen, B. & Holmegaard, S. Urinary cyclic AMP in spot urine of healthy children. Pediatr Res 18, 1224 (1984). https://doi.org/10.1203/00006450-198411000-00141
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DOI: https://doi.org/10.1203/00006450-198411000-00141
