Abstract
Effects of fetal hyperinsulinemia were examined in six chronically catheterized ovine fetus (F), receiving 0.2 U/kg/hr of insulin (I) continuously for 24 hours, followed by 0.4 U/kg/hr of I for an additional 24 hours. Hemodynamic changes (microsphere method), fetal arterial levels of I, glucose (G), norepinephrine (NE) and O2 content were determined at 2 and 24 hours of each infusion period. Data (M±SD) are shown below:
Fetal hyperinsulinemia resulted in increased fetal O2 consumption (FVO2) which in turn produced a surge in catecholamine (NE) release. The latter mediated an increase in CO, with a redistribution of CO providing a greater proportion distributed to the fetus at the expense of the placenta. We speculate that hemodynamic adjustments with a decrease in placental blood flow may occur in pregnancies complicated by fetal hyperinsulinemia.
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Stonestreet, B., Piasecki, G., Oh, W. et al. CARDIOVASCULAR RESPONSES TO INSULIN INFUSIONS IN THE OVINE FETUS. Pediatr Res 18 (Suppl 4), 130 (1984). https://doi.org/10.1203/00006450-198404001-00223
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DOI: https://doi.org/10.1203/00006450-198404001-00223
