Abstract
Since full neuromaturation of the splanchnic adrenomedullary system in the rat pups does not occur until 10 days post delivery, we investigated the CA adrenal content in response to 6 minutes of asphyxia (A) induced by sealing 2 ten day old pups per bag in lab storage bags at T 39.0°C. Immediately upon removal from the bag, each pup was dispatched and trunk blood was collected for blood gas analysis. Control(CT)pups were likewise dispatched and organs taken. Adrenal glands were taken and immediate ly processed for dopamine(DA),norepinephrine(NE) and epinephrine (EPI) concentrations by high performance liquid chromatography with electrochemical detection. The experimental animals showed severe respiratory acidosis without hypoxemia and no depletion of adrenal CA.
Respiratory acidosis without hypoxia does not deplete adrenal CA stores in the 10 day old rat pup. Whether this lack of depletion is related to stressor (asphyxia without hypoxemia)and/or neuromedullary maturation, remains to be determined.
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Zeller, W., Hannigan, J., Menendez, C. et al. ADRENAL CATECHOLAMINE(CA)CONTENT IN ASPHYXIATED 10 DAY OLD RAT PUPS. Pediatr Res 18 (Suppl 4), 148 (1984). https://doi.org/10.1203/00006450-198404001-00331
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DOI: https://doi.org/10.1203/00006450-198404001-00331
