Abstract
Chronic PB treatment may induce vitamin D (D) deficiency with a risk for osteomalacia. Looking for similar risks during pregnancy, 11 epileptic mother-infant pairs (E) were compared to 11 mother-infant controls (C) matched for age, parity, gest. age, birth-weight and season of birth, all without D or Ca supplement. Samples were taken at birth from the mother and the cord, and from the infant on day 2 and 7 for Ca, alkaline phosphatase (AP-bone isoenzyme), 25(OH)D (competitive protein-binding R°-assay) and iPTH blood levels. Ca level in E mothers (x̄ ± SD) is 86.0 ± 2.4 vs 90.6 ± 2.8 mg/L in C (P <.05). All E and 7/10 C mothers show 25(OH)D levels below the normal mean. Cord blood Ca is 99.8 ± 5.2 mg/L in E vs 104.8 ± 5.3 in C infants (NS). In the 1st week 6/11 E infants had at least one hypocalcemic level vs 0/11 in C (P< .01). Increased AP in cord blood (7.4 ± 2.5 BU in E vs 5.4 ± 1.1 in C (P< .05) were correlated with mothers blood levels (P<.01). On day 6 iPTH rose in E infants (P< .05). At birth 25(OH)D level is 17.6 ± 7.1 in E and 19.2 ± 1.7 ng/ml in C (NS) below the standard mean and correlated with mothers levels (P< .05). Abnormal values for all measurements (Ca, AP, D, PTH) were more frequent in group E (P<.05 in mothers, P<.01 in infants) than in group C.
It is suggested that PB treatment during pregnancy induces Ca metabolism impairment, a deficiency in D being partially compensated by regulatory mechanisms.
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Dolisi, C., David, L., Chapuis, M. et al. CALCIUM (Ca) METABOLISM DISTURBANCES DUE TO PHENOBARBITAL (PB) DURING PREGNANCY IN EPILEPTIC MOTHERS AND THEIR INFANT. Pediatr Res 18 (Suppl 4), 152 (1984). https://doi.org/10.1203/00006450-198404001-00352
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DOI: https://doi.org/10.1203/00006450-198404001-00352
