CALCIUM CHANNEL BLOCKADE AS THE TREATMENT OF ENDOTOXIN SHOCK IN NEWBORN PUPPIES

Abstract

Previous studies have shown that pretreatment of adult rats with the calcium channel blocker diltiazem(DZ) attenuates the Endotoxin(ET) induced decrease in cardiac output(CO). We have now measured the CO(cardio-green technique of Arcilla and Rowe), mean arterial pressure(MAP) and heart rate(HR) in 45 new born mongrel puppies. The animals were divided into 3 groups:

I. ET (1.5 mg/kg IV) without DZ; II. DZ (600 μg/kg IV) 20 min. prior to ET; III. (1200 μg/kg IV) 20 min. prior to ET. MAP, CO and HR measurements (mean value± SE, no. of animals given in parentheses) at 1 and 2 hours post Endotoxin.

There was no significant effect of ET or DZ (either dose) on HR. Although ET significantly (P< .05) decreased CO (Pre vs. post ET). DZ pretreatment produced no significant CO changes.

However, MAP was significantly affected by DZ (DZ pretreatment vs ET alone). These results suggest that in newborn puppies ET shock, DZ causes early hypotension w/o affecting CO.

Log in or create a free account to read this content

Gain free access to this article, as well as selected content from this journal and more on nature.com

Access through your institution

or

Sign in or create an account

Continue with Google

Continue with ORCiD