Abstract
Somatomedin-C (SmC) is a peptide mitogen whose serum and tissue levels are considered to be growth hormone dependent. We previously reported that tissue SmC is significantly elevated in regenerating kidneys after contralateral nephrectomy. In the present study, we measured SmC tissue levels in the surgically removed left kidney of 12 wk old hypophysectomized rats and in the remaining kidney 5 days later. Similar measurements were made on kidneys from hypophysectomized rats following sham surgery.
Serum concentrations (nephrectomy: 1.17±0.17 units/ml; sham: 1.09±0.21 units/ml) were no different. Injection of 125I-SmC into nephrectomized and sham operated animals showed no difference in right kidney uptake 5 days after surgery.
Thus, SmC is increased in regenerating kidney tissue even in the absence of growth hormone. Since there was no change in renal uptake of labelled SmC, the changes observed do not reflect renal clearance. (Supported by NIH grant HL-25907)
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Stiles, A., D'Ercole, A. & Smith, B. KIDNEY TISSUE SOMATOMEDIN-C INCREASE AFTER NEPHRECTOMY IS INDEPENDENT OF GROWTH HORMONE. Pediatr Res 18 (Suppl 4), 178 (1984). https://doi.org/10.1203/00006450-198404001-00508
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DOI: https://doi.org/10.1203/00006450-198404001-00508
