NUTRITIONAL ADEQUACY OF FORTIFIED PRETERM HUMAN MILK (PTHM) IN VLBW INFANTS

Abstract

The ability of mother's own PTHM fortified with a protein-mineral supplement (Mead Johnson) to approximate in utero requirements of fat, nitrogen (N₂), calcium (Ca), phosphorus (P), and zinc (Zn) was assessed and compared to a premature formula (Mead Johnson) in 5 VLBW infants (BW 948±67 gm, GA 27.8±0.9 wks, mean ± SEM). Urine and stool were collected separately during a 72 hr interval bracketed by carmine red. Three studies were performed in 3 infants (wt 1230-1540 gm, age 41-74 days) fed fortified-PTHM and 3 in 2 infants (wt 1120-1490 gm, age 27-40 days) fed formula. Fat balance and absorption were 6.31±0.72 gm/kg/d and 93±5% with fortified-PTHM, and 5.63±0.06 gm/kg/d and 93±2% with formula respectively. N₂, Ca, and P balance (mg/kg/d) and % retention are shown below. Zn balance and retention ranged from 256 to 1084 μg/kg/d and 14 to 64% with fortified-PTHM, and -1074 to +258 μg/kg/d and -88 to +22% with formula respectively. In conclusion, the nutritional requirements for fat, N₂, Ca, and P are comparably met by fortified-PTHM and premature formula. However, fortified-PTHM meets Zn needs better.

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