Abstract
An investigational 20% safflower oil emulsion with increased linolenic acid (3±1.5%) was evaluated in ten neonates and compared to a control group of ten receiving 20% safflower oil (0.1% linolenic). A subgroup of five study patients and four controls had received 10% safflower oil prior to the study and were evaluated separately. Mean birthweight for all groups was 1.5kg. Serum fatty acid (FA) profiles were done prior to and after completion of 7 days of fat therapy. Below are fatty acid levels for those infants who had not received previous lipid. (expressed as % total FA)
The subgroup infants who had received 10% safflower oil prior to entering the study had L/A ratio changes that were not statistically different from the control group above. Safflower oil with added linolenic acid appears to inhibit the conversion of linoleic acid to its metabolites as evidenced by a significantly increased L/A ratio. This inhibition was not apparent by L/A ratio in those neonates who had previously received safflower oil.
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Simon, N., Adamkin, D. THE INTERRELATIONSHIP BETWEEN LINOLEIC AND LINOLENIC ACIDS IN NEONATES MAINTAINED ON TPN INCLUDING SAFFLOWER OIL. Pediatr Res 18 (Suppl 4), 214 (1984). https://doi.org/10.1203/00006450-198404001-00724
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DOI: https://doi.org/10.1203/00006450-198404001-00724
