Abstract
Histiocytosis X (HX) is currently believed to be a Langerhans' cell neoplasm. Cell subpopulations in 5 biopsies from 3 cases of HX were scrutinized using an indirect immunoperoxidase technique and 21 McAbs. The following McAbs were used: Leu l(pan T), Leu 3A (Helper T, macrophages), Leu 2A (suppressor T), OKT 3 (pan T), OKT 6 (cortical thymocyte, Langerhans'), HLADR (macrophages, activated T,B), R423 (dendritic reticulum cell), My 3 (monocyte), Leu M1 (myelomonocytic), Leu M3 (monocyte), OKT 9 (transferrin receptor), OKT 10 (prothymocyte, bone marrow progenitor), B1 (B cells), B2 (B subset), T 11 (E receptor), HNK 1 (K/NK), My 10-13 (immature myeloid), J5 (C.A.L.A.). The tumor phenotype was OKT 6+ HIADR+ Leu 3A+. However, cells reacting with Leu 1, Leu 2A, OKT 3, My3, Leu M1, Leu M3, 10, 11, 13 were also present. This study indicates considerable heterogeneity of cells in HX and suggests that numerous cell-cell interactions may be occurring. The OKT 6 marker may be a useful adjunct in the diagnosis of Histiocytosis X.
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McMillan, E., Humphrey, G., Stoneking, L. et al. CELL SUBPOPULATIONS IN HISTIOCYTOSIS X. Pediatr Res 18 (Suppl 4), 245 (1984). https://doi.org/10.1203/00006450-198404001-00910
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DOI: https://doi.org/10.1203/00006450-198404001-00910
