Abstract
H-X consists of a spectrum of diseases of unknown etiology with variable clinical expression. The histology of lesions suggests this disease is immunoreactive and not neoplastic. In order to determine whether patients with active disease lack suppressor cells and/or activity, we examined children with active and inactive disease. The percentage and absolute number of T lymphocytes and their subsets (T11, T4, T8, T10, T6), B lymphocytes and natural killer cells (Leulla) were examined in addition to suppressor activities of mononuclear cells. No significant differences were noted on any parameter between patients with inactive disease (n=14) and age-matched controls (n=22). However, the following was noted between patients with active disease (n= 7) and age-matched controls (n=7).
*P<0.05, x±SD
These results show a lack of lymphocyte and monocyte suppressor function in patients with active disease.
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Shannon, B., Newton, W. & Jacobs, D. 938 LACK OF SUPPRESSOR CELL ACTIVITY IN CHILDREN WITH HISTIOCYTOSIS-X (H-X). Pediatr Res 19, 267 (1985). https://doi.org/10.1203/00006450-198504000-00968
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DOI: https://doi.org/10.1203/00006450-198504000-00968
