Abstract
Rat thymocytes stimulated with Concanavalin-A (Con-A), in the presence of Luminol respond with a short lived burst of chemiluminescence (CL) associated with H202 production. Macrophage depleted thymocytes are also said to react similarly. 2.5 × 107 to 1 × 108 thymocytes obtained from thymi resected during open heart surgery similarly responded to luminol augmented Con-A stimulation. Addition of latex particles further increased CL 5 to 10 folds. However partial elimination of macrophages by carbonyl-iron ingestion or by adherence to plastic surfaces reduced CL 5 to 7 fold from the initial values. Thymocyte CL may be a function of macrophages contaminating the cell suspension.
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Fikrig, S., Suntharalingam, K. 974 HUMAN THYMOCYTE CHEMILUMINESCENCE-DEPENDENCE ON MACROPHAGES. Pediatr Res 19, 273 (1985). https://doi.org/10.1203/00006450-198504000-01004
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DOI: https://doi.org/10.1203/00006450-198504000-01004
