Abstract
A wide spectrum of chronic-reactivation infections due to EBV has been documented in patients with or without primary immunodeficiencies. Recently, we found evidence suggesting EBV as the cause of recurrent aseptic meningitis. This male child presented several years beforehand with recurrent urticaria, arthralgias, chronic papillitis, neurosensory hearing loss, and 5 episodes of aseptic meningitis (last episode at 13.2 yr.). CSF during acute episodes contained up to 1×104 leukocytes/mm3 (principally neutrophils), elevated proteins (70-250mg/dl), but no microorganisms. B and T cell functions appeared normal. Serum antibodies to EBV were:
In addition, CSF contained IgG antibodies (1:5) to the capsid antigen. Thus, the chronic-recurrent central nervous system abnormalities may be due to EBV. EBV genes and antigens in the child's cells and immune response of the patient to EBV are being investigated.
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Kantak, A., Brosnan, P., Chonmaitree, T. et al. 1118 CHRONIC-REACTIVATION EBSTEIN-BAR VIRUS (EBV) INFECTION PRESENTING AS RECURRENT ASEPTIC MENINGITIS. Pediatr Res 19, 297 (1985). https://doi.org/10.1203/00006450-198504000-01148
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DOI: https://doi.org/10.1203/00006450-198504000-01148
