Abstract
Detection of gestational diabetes (GD) is currently limited to the last trimester, whereas the associated letal abnormalities occur early in pregnancy due to disturbances in maternal metabolism. He have studied 39 pregnant subjects with varying degrees of carbohydrate tolerance at intervals during pregnancy. Heparinized blood samples (10-15cc) were obtained from all subjects after an overnight fast, for studies of [125]I-insulin binding, membrane phospholipid (PL) and membrane fluidity determinations using fluorescence polarization (FP).
The data suggest that a detect in insulin binding and insulin action is present in women with GD, associated with disturbances in both membrane structure and biophysical behavior. This detect, similar to that seen in obese. Type II diabetic subjects is detectable betore 12 weeks gestation. Early detection ot GD, permitting the institution of appropriate measures of metabolic control in these subjects, should result in marked reduction of perinatal morbidity.
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Neufeld, N., Corbo, L. & Brunnermanulla, S. 1239 DETECTION OF GESTATIONAL DIABETES IN THE FIRST TRIMESTER: ABNORMALITIES IN CELL MEMBRANE STRUCTURE AND FUNCTION. Pediatr Res 19, 317 (1985). https://doi.org/10.1203/00006450-198504000-01269
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DOI: https://doi.org/10.1203/00006450-198504000-01269
