Abstract
BR inhibits in vitro oxidative phosphorylation and glycolysis. This study investigated the in vivo effect of BR on O2 consumption (VO2), O2 extraction (O2-Ex), glucose consumption (VGlu), and glucose extraction (GluEx) in the CE. Sixteen 2-4 day old P were studied in 3 groups: 1) control (C) 2) control with sulfisoxazole (CS) and 3) experimental (E). CS and E received sulfisoxazole. E was infused with BR for 4 hrs to maintain the serum BR of 13.2±1.8 mg% (M±SEM). CE BR in E was 6.7±.8 μg/gm of CE (M±SEM). CE blood flow (microsphere method) and aorta-superior sagittal sinus differences in O2, content and glucose were measured to calculate VO2, O2Ex, VGlu, and GluEx. No changes were noted in VO2 or O2Ex. VGlu was increased in CS, but not in E. The mean reduction in arterial glucose of 53.3 mg/dl in all groups (p<0.05), over the four hours of study, was associated with increased GluEx in CS and C, but not in E. We speculate that BR may alter GluEx, but has no major effect on VO2 or O2Ex.
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Brann, B., Stonestreet, B., Oh, W. et al. 1350 THE EFFECT OF BILIRUBIN (BR) ON CEREBRAL CORTEX (CE) O2 AND GLUCOSE METABOLISM IN PIGLETS (P). Pediatr Res 19, 335 (1985). https://doi.org/10.1203/00006450-198504000-01374
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DOI: https://doi.org/10.1203/00006450-198504000-01374
