1356 THE EFFECT OF PHENOBARBITAL (PB) ON CEREBRAL BLOOD FLOW VELOCITY (CBFV) FOLLOWING ENDOTRACHEAL UZ3U SUCTION (ETS)

Abstract

ETS produces a transient fall in PaO₂ and a rise in mean arterial blood pressure (MABP). PB may decrease the neonatal response of CBFV as a result of ETS. 7 infants, mean birthweight 819g and mean gestational age of 27 wks, were studied in the first 20 hrs of life. Area under the velocity curve (AVC), peak systolic velocity (PSV), and end diastolic velocity (EDV) were measured with a doppler velocimeter before (C) and after (S) ETS at 3 time periods: prior to PB (baseline: 0), 2 hrs after and 4 hrs after an i.v. dose of 20 mg PB/kg. Heart rate, mean arterial blood pressure (MABP) and transcutaneous PO₂(T_c PO₂) were measured simultaneously with the doppler determinations.

There were no changes at any time with PSV (values: 7.4 cm/sec) and EDV (values: 2.1 cm/sec). As shown above, ETS produced a significant rise in MABP and a fall in T_cPO₂. Four hours following PB treatment, the percent change in ΔAVC associated with ETS was reduced. We speculate that PB may modulate the response of ΔAVC to ETS.

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