1363 PGE₁ AND NEONATAL CEREBRAL BLOOD FLOW

Abstract

Alterations in regional cerebral blood flow (rCBF) may be critical in the genesis of intra-ventricular hemorrhage and hypoxicischemia encephalopathy. rCBF regulation is mediated via several factors including prostaglandins (PG). The effect of PGE₁, the most commonly used PG in the newborn period, on rCBF was evaluated in 6 piglets, 1-3 d.o. Aorta, inferior vena cava, left ventricle and sagittal vein were catheterized to monitor blood gas, glucose and pressure. PGE₁ was administered in the left internal carotid artery in successive increasing doses of 10⁻⁷, 10⁻⁶, and 10⁻⁵ g/kg/bolus q 20 mins, to awake piglets. rCBF was measured by radiolabelled microspheres (¹⁴¹Ce, ⁴⁶Sr, ⁸⁵Nb, ⁹⁵Sc) 45 sec post bolus.

PGE₁ doses of 10⁻⁷ g/kg produced a 40% decrease in rCBF.In contrast, no effect was observed at higher doses. Blood pressure and gases remained constant during the study. There was no correlation between blood pressure and rCBF at all doses of PGE₁. However, there was a positive correlation between cerebral resistance rCBF only at the dose of 10⁻⁷ g/kg PGE₁. This implies that physiological concentration of PGE₁ (10⁻⁷ g/kg) as found in adult cerebral vessels, may contribute to neonatal rCBF autoregulation.

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