Abstract
We have measured levels of pulmonary apoprotein (Apo) in tracheal aspirates (TA) of infants with RDS during the course of their treatment. This was done with an ELISA capable of detecting concentrations as low as 10 ng/ml in samples as small as 50 ul. The assay employs an affinity-purified rabbit IgG raised against human apoproteins. A similar assay was established to measure albumin (Alb) in the same samples. Determinations were also made on amniotic fluid (AF) of full-term infants and infants subsequently developing RDS. TA samples from infants with RDS were obtained within six hours of birth and then daily while intubated. Values shown below are from TA's soon after birth, and 3-4 days of age when the infants were recovering from RDS.
We conclude that this measure will be useful not only for prediction of RDS, but also for postnatal diagnosis and assessment of clinical course.
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Chida, S., Taeusch, H., Phelps, D. et al. 1365 SURFACTANT APOPROTEINS IN INFANTS WITH RESPIRATORY DISTRESS SYNDROME (RDS). Pediatr Res 19, 338 (1985). https://doi.org/10.1203/00006450-198504000-01389
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DOI: https://doi.org/10.1203/00006450-198504000-01389
