1507 NEUROMUSCULAR OUTCOME IN INFANTS UNDER 1001 GM STUDIED PROSPECTIVELY WITH ECHOENCEPHALOGRAPHY (ECHO) FOR INTRACRANIAL HEMORRHAGE (ICH)

Abstract

All infants under 1001 gms were studied prospectively with ECHO within 24 hrs of admission to the Stanford ICN between 1/1/80 and 6/30/83. They were re-evaluated at least twice weekly, and scored by Papille's classification for ICH and for atrophy and hydrocephalus (HC). Of the 150 infants, 92 (61%) were discharged and examined yearly. Seven were excluded (4 deaths, 1 encephalocele, 1 lost to followup, 1 late non-neonatal neurologic injury). (± SD)

These data suggest that although infants with Grade I & II ICH have more abnormal neurodevelopmental (ND) exams, these infants still have good potential for normal neurological function (74%). However, infants with Grade III & IV ICH or isolated atrophy and/or HC may have a poorer prognosis, with no normal exams. Infants with a normal ECHO but an abnormal exam had low birth weights when compared to those with a normal ND exam and also had serious complications of Candida sepsis (3), asphyxia (1), hypothyroidism (1), pneumonia (1), and histiocytosis X (1).

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