1566 NEONATAL GLUCOSE DYSHCMEOSTASIS IN A RAT PUP MODEL OF SEPSIS

Abstract

Endotoxin(ETN) plays a significant role in the morbidity and mortality of newborn sepsis. Hypoglycemia and lactic acidosis are prominent in sepsis neonatorium. The pathogenesis of this hypoglycemia is unknown. S. Enteritidis ETN was given to 10 day old 4 hour fasted, temperature controlled groups(n = 15) of controls(CT), mild sepsis, ED₂₀(.03mg/kg I.P.), and severe sepsis ED₉₀(0.1mg/kg I.P.). Pups were dispatched at 0,½,2,3, and 4 hours. Standard analyses were used for glucose (G,mg/dl), lactate (L,mmole/L), and insulin (I,uU/ml).

These data demonstrate that the hypoglycemic trend (p <.05) seen at 4 hours in the LD₉₀ group is not the result of hyperinsulinemia. The elevated lactate levels(p < .05) at 4 hours indicate anaerobic metabolic compensation.

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