Abstract
In order to study the effects of vitamin D on aluminum excretion when different forms of vitamin D and phosphate-binders are used simultaneously for therapeutic purposes, 30 Sprague-Dawley weanling rats, weighing 44 to 66 gm, were randomly assigned to five groups: (A) control, (B) aluminum hydroxide, (C) DHT at 16 mcg/kg/day, (D) 1,25-D at 16 ng/kg/day and (E) vitamin D2 at 2,000 lU/kg/day. Aluminum hydroxide (60 mg/kg/day) in the feed was provided to all except the control group. The vitamin D or metabolites were fed by stomach tube daily for a period of 10 days. At the end of the study, the mean serum aluminum concentration, as determined by flameless atomic absorption spectrophotometry, was 5.0 mcg/l; there was no significant differences in these results between groups. During the last three days of the study, 24-hour urine collections were made with the usual precautions against trace mineral contamination. The means (SEM) of aluminum excretion in mcg/100 gram body weight/day were:
Thus, urinary aluminum excretions doubled with treatment but were not significantly different between treated groups compared to control except between groups A and E, (p < 0.05). We conclude that at therapeutic doses of aluminum hydroxide and vitamin D or metabolites, hyperaluminemia was not observed, and urinary aluminum excretions were not significantly different between treated groups.
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Chan, J., Jacob, M., Brown, S. et al. 1582 ALUMINUM HYDROXIDE, VITAMIN D, DIHYDROTACHYSTEROL (DHT), 1,25-DIHYDROXYVITAMIN-D (1,25-D) ON ALUMINUM EXCRETION IN RATS. Pediatr Res 19, 374 (1985). https://doi.org/10.1203/00006450-198504000-01606
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DOI: https://doi.org/10.1203/00006450-198504000-01606
