Abstract
Generalized aminoaciduria and high urinary calcium/urinary creatinine (Cr) seen in infants <1500 g birthweight fed mineral supplemented formulae are not related to the higher protein content of the formula (3.0g/100Kcal)(SPR abst 1985). We thus evaluated the effects of increased calcium intake on proximal tubular function using both NAG and β2M as suggested markers of proximal tubule damage. Serial urine samples from 14 infants fed a standard formula (S)(510mg/L Ca, 390mg/L P) and 21 infants fed mineral supplemented formulae (E)(950mg/L Ca, 480mg/L P) were analyzed for NAG and β2M using enzymatic assays and both values corrected for Cr. Although variation was great, no difference in either mean±SD NAG (mmol/mg Cr) or β2M (mg/L/mg Cr) was seen between infants on S or E. 3 infants on Methicillin and Gentamicin had NAG >200 mmol (>2SD) and 4 hypoproteinemic infants had both NAG <5 (<2SD) and β2M <.05 (data on these 7 infants excluded from mean calculations seen in table). Though continued study is needed to define optimal mineral supplementation, these data are reassuring that the aminoaciduria seen probably represents renal immaturity or transport competition rather than tubular damage.
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Hillman, L., Salmons, S., Erickson, M. et al. 1603 URINE N-ACETYL-β-D-GLUCOSAMINIDASE(NAG) AND β2-MICRO-GLOBULINS (B2M) IN VERY LOW BIRTHWEIGHT INFANTS FED MINERAL SUPPLEMENTED FORMULA. Pediatr Res 19, 378 (1985). https://doi.org/10.1203/00006450-198504000-01627
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DOI: https://doi.org/10.1203/00006450-198504000-01627
